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Active contour Arteriolar-to-venular ratio artery/vein classification bifurcation Blood vessels computer-aided diagnosis Diabetes diabetes mellitus diabetic retinopathy DRS Feature extraction fovea fractal dimension graph Image segmentation MMSE Noise Reduction Optic disc detection orientation score (OS) Orientation scores Retina RetinaCAD RetinaCheck Retinal image Retinal image analysis retinal images speech processing vessel biomarkers Vessel segmentation Vessel width